A revolution in medicine is under way, and everyone will benefit - as patients and as taxpayers. Precision medicine uses genomics, medical devices, computer science and other fields to treat individual patients, instead of broad populations, with the safest and most effective therapies for their specific conditions. This offers hope of better treatments and cures for the very young (birth defects), the very old (neurodegenerative diseases like Alzheimer's) and everyone who is at risk for cancer. California is the global center of information technology, social media tools and mobile applications, and it also boasts top-tier medical research centers. How can the Golden State build on those assets and expand its role as a powerhouse of precision medicine innovation? How can we corral collaborative investments by industry, academic research institutions and government to accelerate progress against disease? What will the benefits for California's economy be?